Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissues

Publication date: Available online 15 January 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Carta Gianfranca, Murru Elisabetta, Vargiu Romina, Collu Maria, Carta Manolo, Banni Sebastiano, Stancampiano RobertoAbstractNo data are available on whether a diet deficient of the essential fatty acids is able to modulate tissue levels of endocannabinoids and congeners.Male rats fed for 12 weeks a diet deficient of essential fatty acids, palmitic and oleic acids (EFAD), replaced with saturated fatty acids (SAFA), showed lowered n-3 and n-6 PUFAs levels in plasma, liver and adipose tissue, with concomitant steep increase of oleic and mead acids, while in hypothalamus no changes in PUFA concentration were detected and only palmitoleic acid was found increased. We found a reduction of anandamide and palmitoylethanolamide in liver, adipose tissue and brain, while oleoylethanolamide increased significantly in liver and adipose tissue, associated to a 50 % body weight decrease.Changes in N-acylethanolamide profile may contribute to body weight reduction distinctive of EFA deficiency.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research