Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism

ConclusionsIn patients with acute submassive PE, despite evidence of adequate drug delivery, inhaled NO had no major effect on platelet O2 consumption or agonist-stimulated parameters on TEG. Pharmacological activation, but not stimulation, of sGC effectively decreased platelet cytosolic [Ca++], and platelet sGC activity was increased with PE, confirming the viability of sGC as a therapeutic target.Graphical abstract
Source: Nitric Oxide - Category: Chemistry Source Type: research