Drug Screen Tugs at Common Thread for Repeat Disorders

Publication date: Available online 8 January 2020Source: Trends in Pharmacological SciencesAuthor(s): Kaalak Reddy, John Douglas Cleary, J. Andrew BerglundRepeat-associated non-ATG (RAN) translation is emerging as a driver of pathogenesis in microsatellite expansion disorders. Green and colleagues recently identified several candidate RAN translation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndrome. Their study establishes a path forward for identifying inhibitors of RAN translation for multiple disorders.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research