Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin ‐induced gastric mucosal injury: involvement of TFF1‐mediated EGF/EGFR and apoptotic pathways

ConclusionsOur present study demonstrated that TCS ’s gastroprotective effect was closely connected with boosting TFF1 expression, activating TFF1‐mediated EGF/EGFR pathway, thus restraining mitochondrial‐dependent apoptosis, which provided new insights into interpreting its underlying mechanism and promised to act as a candidate drug to treat gastric mucosal injury.

Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Yuanyuan Zhang, Haiyan Xu, Haibo He, Xiaomei Li, Minlu Feng, Yumin He, Weijie Jiang, Junzhi Wang, Daoxiang Xu, Kun Zou Tags: Research Paper Source Type: research