7 ‐methoxyflavanone alleviates neuroinflammation in lipopolysaccharide‐stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO‐1 pathway

Conclusions7 ‐methoxyflavanone inhibited LPS‐stimulated TLR4/MyD88/MAPK signalling and activated Nrf2‐mediated transcription of antioxidant protein NQO‐1, showing antineuroinflammatory effect, so it is a potential neuroprotective agent.

Source: Journal of Pharmacy and Pharmacology - December 21, 2019 Category: Drugs & Pharmacology Authors: Zhao Qu, Yan Chen, Zhuo ‐Hui Luo, Xiao‐Ling Shen, Ying‐Jie Hu Tags: Research Paper Source Type: research