Human junctophilin-2 undergoes a structural rearrangement upon binding phosphatidylinositol (3,4,5) triphosphate {-} the S101R mutation identified in hypertrophic cardiomyopathy obviates this response

In conclusion this study provides new insights into the structural and lipid binding properties of JP2 and how the S101R mutation may impact upon the stability of the dyad organization with the potential to alter JP2-protein interactions regulating Ca2+ cycling.

http://www.biochemj.org/bj/imps/refer.htm?MSID=BJ20130591

Source: BJ Cell - September 4, 2013 Category: Biochemistry Authors: H J. Bennett, J Bernard Davenport, R F. Collins, A W. Trafford, C Pinali, A Kitmitto Tags: BJ Cell Source Type: research