The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population [Patient-Oriented and Epidemiological Research]

Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.

Source: The Journal of Lipid Research - December 31, 2019 Category: Lipidology Authors: Nishida, Y., Hachiya, T., Hara, M., Shimanoe, C., Tanaka, K., Sutoh, Y., Shimizu, A., Hishida, A., Tsukamoto, M., Kadomatsu, Y., Oze, I., Koyanagi, Y. N., Kuriyama, N., Koyama, T., Ibusuki, R., Takezaki, T., Ikezaki, H., Furusyo, N., Takashima, N., Kadota Tags: Patient-Oriented and Epidemiological Research Source Type: research