Goat Mesenchymal Stem cell Basic Research and Potential Applications

Publication date: Available online 31 December 2019Source: Small Ruminant ResearchAuthor(s): Mudasir Bashir Gugjoo, Amarpal, Mujeeb ur Rehman Fazili, Riaz Ahmad Shah, Masood Saleem Mir, Gutulla Taru SharmaAbstractStem cell, one of the most exciting research areas of 21st century, is considered to have broaden the horizons of the field of biology, in general and medicine, in particular. Stem cells, owing to their unique characteristics like self-renewal, multiplication and differentiation are considered to provide an ‘all-in-one-solution’ for diverse clinical problems. Among various stem cell types, mesenchymal stem cells (MSCs) are being made the subject of the most of the studies on their therapeutic applications. It is attributable to their readily available sources, ability to immunemodulate and differentiate into mesodermal and extra-mesodermal tissues. MSCs in contrast to pluripotent stem cells carry minimal risk of teratoma formation and are free from any ethical concern. MSCs have been evaluated under innumerable studies but the definitive applications of these cells are slow, plausibly due to the incomplete understanding of their cellular physiology. Goat MSCs (gMSCs) have been isolated, culture expanded, characterized from various tissue sources and studied for their potential in vivo applications mostly in relation to human translational models. The current review throws some light on gMSC sources, characterization and potential therapeutic applications.
Source: Small Ruminant Research - Category: Zoology Source Type: research