Formulation and in vitro evaluation of fast dissolving tablets of Febuxostat using co-processed excipients.

Formulation and in vitro evaluation of fast dissolving tablets of Febuxostat using co-processed excipients. Recent Pat Drug Deliv Formul. 2019 Dec 24;: Authors: Kaur M, Mittal A, Gulati M, Sharma D, Kumar R Abstract Febuxostat is a novel, orally administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate limited absorption. The aim of the current work was to provide a novel strategy to improve the dissolution profile and thus, bioavailability of Febuxostat. Formulation of fast dissolving tablets (FDT) is anticipated to provide immediate release of drug, which in turn, will improve its dissolution profile to provide the initial surge in plasma concentration required in acute gout attack. Incorporation of co-processed excipients in a tablet is known to improve the compressibility and disintegration characteristics of the tablets, which, in turn, result in enhanced in vitro drug release and improved bioavailability. A combination of crospovidone (it rapidly wicks saliva into the tablet to create the volume development and hydrostatic weight important to give quick disintegration) and microcrystalline cellulose (highly compressible ingredient with good wicking and absorbing capacity) was, therefore, used as co-processed excipients. The tablets were prepared by direct compression technique wi...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research