Induction of Cell Death in Renal Cell Carcinoma With Combination of D-Fraction and Vitamin C

Conclusion. The present study demonstrates that the combination of PDF and VC can become highly cytotoxic, inducing severe cell death in ACHN cells. This cytotoxic mechanism appears to be primarily attributed to oxidative stress, accompanied by a G1 cell cycle arrest. Such cell death induced by PDF + VC could be more likely linked to apoptosis, as indicated by the modulation of apoptosis regulators (Bcl2, Bax, and PARP). Therefore, as PDF and VC may work synergistically to induce apoptotic cell death, they may have clinical implications in an alternative, improved therapeutic modality for advanced RCC.

Source: Integrative Cancer Therapies - August 27, 2013 Category: Cancer & Oncology Authors: Alexander, B., Fishman, A. I., Eshghi, M., Choudhury, M., Konno, S. Tags: Articles Source Type: research