Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis

Conclusion: The translocation t(14;21)(q11;q22) occurs in some pediatric T-cell lymphoblastic malignancies. Activation of both OLIG1 and OLIG2 by t(14;21)(q11;q22) in T-lymphoblasts and the ensuing deregulation of thousands of genes could explain the highly malignant disease and resistance to treatment that has characterized this small group of patients.

Source: Cancer Genomics and Proteomics - December 26, 2019 Category: Cancer & Oncology Authors: PANAGOPOULOS, I., GORUNOVA, L., JOHANNSDOTTIR, I. M. R., ANDERSEN, K., HOLTH, A., BEISKE, K., HEIM, S. Tags: Article Source Type: research