Pangenomics Comes of Age: From Bacteria to Plant and Animal Applications

Publication date: Available online 24 December 2019Source: Trends in GeneticsAuthor(s): Agnieszka A. Golicz, Philipp E. Bayer, Prem L. Bhalla, Jacqueline Batley, David EdwardsThe pangenome refers to a collection of genomic sequence found in the entire species or population rather than in a single individual; the sequence can be core, present in all individuals, or accessory (variable or dispensable), found in a subset of individuals only. While pangenomic studies were first undertaken in bacterial species, developments in genome sequencing and assembly approaches have allowed construction of pangenomes for eukaryotic organisms, fungi, plants, and animals, including two large-scale human pangenome projects. Analysis of the these pangenomes revealed key differences, most likely stemming from divergent evolutionary histories, but also surprising similarities.

Source: Trends in Genetics - December 25, 2019 Category: Genetics & Stem Cells Source Type: research