Methionine Pretreatment Enhances the Effects of Valproate on Axial Development in a CD1 Mouse Model

CONCLUSIONSOur data suggest that Met pretreatment enhances the effects of VPA in deregulating the epigenetic control of gene expression in somites, and by consequence, induces more extended dysmorphogenic effects along the axial axis.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - June 1, 2013 Category: Perinatology & Neonatology Authors: Francesca Di Renzo, Erminio Giavini, Elena Menegola Tags: Original Article Source Type: research