Yellow Roses

Wednesday, May 25, 2016:My sweeties and I bought a nice bouquet of yellow roses to celebrate my latest treatment results. In the last four weeks on Pomalyst (pomalidomide)(POM) and Darzalex (daratumumab)(DARA) my IgG has dropped 20% from 807 to 644 mg/dL, and M-spike 25% from 0.8 to 0.6 g/dL. These numbers are the lowest that I have seen in my 13 years with myeloma. Not all of that progress comes in the last four weeks, of course. Here is a chronology of treatments and results since January, 2016:Wed Feb 17 First Zometa infusion, serious reaction to something, likely the Zometa (not relevant to these results). Still on two-MAB trial. Wed Mar 9 Last trial-drug infusion, then next day PET shows myeloma progression, stop trial and start POM immediately, 2 mg daily& 40 mg dexamethasone (DEX) weekly. Thu Mar 24 Myeloma markers tested after 2 weeks on POM/DEX& trial drug, which has a half life of about four weeks. Numbers down, see chart. Tue Apr 05 After 4 weeks on POM/DEX& trial drug, M-spike down but can ' t continue trial drug, start DARA next day. Mon Apr 25 After 3 weeks of POM/DEX& DARA plus fading trial drug, markers down significantly. Wed May 25 After 7 weeks of POM/DEX& DARA, IgG and M-spike down to all-time lows. Currently all of the immunoglobulins that we measure, IgG, IgA, and IgM, are below the bottom of their respective reference ranges and lower than I have ever seen any of them. Implicatio...
Source: Myeloma Hope - Category: Cancer & Oncology Tags: daratumumab Darzalex DEX dexamethasone IgG immunoglobulins M-Spike pomalidomide Pomalyst Source Type: blogs