Exploring the protective potential of carboxymethyl Terminalia catappa polysaccharide on blue light light-emitting diode induced corneal damage.

Exploring the protective potential of carboxymethyl Terminalia catappa polysaccharide on blue light light-emitting diode induced corneal damage. Recent Pat Drug Deliv Formul. 2019 Dec 17;: Authors: Chandel L, Sharma R, Rana V Abstract Excessive blue light light-emitting diode (LED) exposure and consequent oxidative stress causes corneal damage and corneal injuries are the major problem arises these days due to excessive use of mobile phone, TV, environment pollution, etc. In the present investigation, the protectiveness of carboxymethyl Terminalia catappa (CTC) from blue light LED-induced corneal damage was explored. For this purpose, Terminalia catappa (TC) was functionalized by carboxymethylation and its structural modification was confirmed by spectral attributes. Further, the CTC protective eye drop formulations (0.025-1%, w/v) were prepared and evaluated for their capability of protection from blue light LED-induced corneal damage as compared to CTC protective eye gel (1.25-7%, w/v). The findings pointed towards excellent protection of CTC gel formulations as compared to CTC eye drop formulations. In addition, the prepared optimized CTC gel had thixotropic behavior as evident from percentage structural recovery which was 1.75 fold higher than marketed formulation (I-Comfort, HPMC 2%, w/v). The safety and non-toxicity of CTC protective eye drop and gel was confirmed by HET-CAM test. Further, a rat eye model was implemented that m...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research