Integration of Autophagy and Anoikis Resistance in Solid Tumors

ABSTRACT
Macroautophagy or autophagy is a lysosome‐dependent process in which enzymatic degradation and recycling of cytosolic components occurred due to stressful conditions. This cellular arrangement imparts anoikis resistance in solid tumors. Anoikis, a special form of apoptosis occurring when cells detach from the extracellular matrix, is a critical mechanism in maintaining tissue homeostasis and development. Anoikis resistance facilitates tumorigenesis and metastasis. However, the complexity of the role of autophagy in tumor is underscored by evidence that autophagy can function as both a pro‐survival or pro‐death depending on the context and the stimuli, which are likely exploitable for tumor therapy. This review focuses on recent progress in understanding anoikis resistance and autophagy signaling, paying particular attention to its relevance in solid tumor metastasis. Anat Rec, 2013. © 2013 Wiley Periodicals, Inc.

Source: The Anatomical Record Part B: The New Anatomist - August 20, 2013 Category: Anatomy Authors: Jie Yang, Zhichao Zheng, Xiaojie Yan, Xia Li, Zhe Liu, Zhenyi Ma Tags: Review Source Type: research