Multiscale modelling of coupled Ca2+ channels using coloured stochastic Petri nets

In this study, the authors address this problem using coloured stochastic Petri nets SPNc as high-level description to generate continuous-time Markov chains. The authors develop several models with increasing complexity. They first apply SPNc to model single clusters of coupled Ca2+ channels arranged in a regular or irregular lattice, where they describe how to represent the geometrical arrangement of Ca2+ channels relative to each other using colours. They then apply this modelling idea to construct more complex models by modelling spatially arranged clusters of channels. The authors?? models can be easily reproduced and adapted to different scenarios.

Source: IET Systems Biology - August 1, 2013 Category: Biology Source Type: research