Generation of a robust model for inducing autoimmune arthritis in Sprague Dawley rats

DiscussionIn a head-to-head comparison between SD and Wistar rats, the disease profile was better sustained and consistent in SD rats, and the use of CII with low dose CFA and LPS induced features akin to human RA. Taken together, a reproducible model of arthritis was established which can be replicated in any laboratory with limited resources.
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research