p53 death signal is mainly mediated by Nuc1(EndoG) in the yeast Saccharomyces cerevisiae

Abstract
The tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. In the yeast Saccharomyces cerevisiae, the overexpression of the human p53 leads to growth inhibition and apoptotic cell death on minimal medium. In the present work, we show that p53‐expressing cells are more susceptible to cell death after an apoptotic stimulus such as H2O2. The analysis of mutants involved in yeast apoptosis‐like death suggests that the observed cell death is Yca1 independent and mainly mediated through Nuc1p.

Source: FEMS Yeast Research - August 12, 2013 Category: Research Authors: Vanessa Palermo, Eleonora Mangiapelo, Cristina Piloto, Luisa Pieri, Michela Muscolini, Loretta Tuosto, Cristina Mazzoni Tags: Research Article Source Type: research