The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells

Conclusions: Although primary high-grade serous OvCa cells may depend on KIF14 for in vitro proliferation we were unable to demonstrate a role for KIF14 on tumorigenicity or develop an in vivo model for assessment. We have, however developed an effective in vitro method to evaluate the effect of target gene manipulation on the proliferative capacity of primary OvCa cultures.
Source: Journal of Ovarian Research - Category: Cancer & Oncology Authors: Source Type: research