Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

Publication date: Available online 10 December 2019Source: Progress in Natural Science: Materials InternationalAuthor(s): Thi Ngoc Tram Nguyen, Diem-Huong Nguyen-Tran, Long Giang Bach, Tran Hoang Du Truong, Ngoc Thuy Trang Le, Dai Hai NguyenAbstractA hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin (DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the system. Characterization with transmission electron microscopy (TEM) and scanning electron microscopy (SEM), X-ray diffraction (XRD), nitrogen adsorption-desorption, thermogravimetric analysis (TGA) and Fourier transformed infrared (FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.Graphical abstract
Source: Progress in Natural Science: Materials International - Category: Materials Science Source Type: research