Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

Conclusion: These studies suggest PAR1 inhibition initiated after ischemic injury attenuates adverse LV remodeling through late-stage antifibrotic events.

http://cpt.sagepub.com/cgi/content/abstract/18/5/460?rss=1

Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 12, 2013 Category: Cardiology Authors: Sonin, D. L., Wakatsuki, T., Routhu, K. V., Harmann, L. M., Petersen, M., Meyer, J., Strande, J. L. Tags: Experimental Studies Source Type: research