Increasing Doses of Simvastatin Versus Combined Ezetimibe/Simvastatin: Effect on Circulating Endothelial Progenitor Cells

Conclusions:
Among stable patients with CAD and with an LDL-C >70 mg/dL on simvastatin 20 mg, increasing simvastatin dose to 80 mg or adding ezetimibe 10 mg promoted similar further cholesterol reduction but did not have incremental effects on circulating EPCs. These data suggest that the effects of simvastatin moderate doses on EPCs are not increased by intensive lipid-lowering strategies (clinicaltrials.gov: NCT00474123).

Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 12, 2013 Category: Cardiology Authors: Pesaro, A. E. P., Serrano, C. V., Katz, M., Marti, L., Fernandes, J. L., Parra, P. R. G., Campos, A. H. Tags: Clinical Studies Source Type: research