Different doses of tannin reflect a double-edged impact on broiler chicken immunity

Publication date: Available online 9 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Amany Ramah, Masahiro Yasuda, Yuki Ohashi, Marimu Urakawa, Tetsuo Kida, Tenya Yanagita, Ryoko Uemura, Hatem H. Bakery, Nabila M. Abdelaleem, Elham A. El-ShewyAbstractTannin is one of the most common phytochemical secondary phenolic metabolites, which is widely distributed in various plant production systems. Dietary intake of tannin can exert different actions on the immune system. The aim of this study was to evaluate the influence of different concentrations on broiler chicken immunity. Three groups (n = 10 in each group) were evaluated: control group given a normal basal diet, high tannic acid (HT) group given high-dose tannic acid (30 g/kg diet) and low tannic acid (LT) group given low-dose tannic acid (0.5 g/kg diet) for 35 days. Feed intake and body weight were measured weekly. Cells were isolated from thymus, spleen and caecal tonsils at the end of the study. Lymphocyte subsets, monocytes phagocytosis and cytokine mRNA expression in spleen were evaluated. The results showed that HT group chickens had decreased daily gain, final body weight, daily feed intake and relative weights of lymphoid organs compared with other groups. In thymus, spleen and caecal tonsils, relative CD4+, CD8+, CD4+CD8+ and γδ+ cell populations in the HT group were significant decreased in comparison with those of other groups. The relative B cell population in the HT group was a...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research