Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences

Conclusions:
This is the first study showing a direct isolation method of myofibroblasts and fibroblasts from injured lungs. We demonstrated functional similarities and differences between myofibroblasts and fibroblasts in terms of both their proliferative capacity and the expression levels of genes for collagen, collagen synthesis enzymes, and chemokines. Thus, this direct isolation method has great potential for obtaining useful information from myofibroblasts and fibroblasts.

Source: Fibrogenesis and Tissue Repair - August 8, 2013 Category: Biomedical Science Authors: Taisuke AkamatsuYosifumi AraiIsao KosugiHideya KawasakiShiori MeguroMakiko SakaoKiyoshi ShibataTakafumi SudaKingo ChidaToshihide Iwashita Source Type: research