Polyacelylenic alcohols and alkaloid derivatives from a calcareous marine sponge, Leucetta chagosensis

Publication date: February 2020Source: Biochemical Systematics and Ecology, Volume 88Author(s): Xiao-Hong Sun, Ron-Ping Zhao, Yan Chen, Shuang Li, Wei-Zhuo TangAbstractA chemical investigation of the CH2Cl2 extract of the marine sponge Leucetta chagosensis afforded 8 secondary metabolites, namely, pellynol A (1), pellynol B (2), pellynol I (3), pellynol D (4), plakohypaphorine B (5), plakohypaphorine E (6), 4-bromo-1H-pyrrole-3-carboxamide (7), and 2-phenylacetamide (8). The structures of these secondary metabolites were elucidated via NMR spectroscopic analysis, MS experiment and compared with those reported in the literature. This is the first report of compounds 1–8 isolated from the marine sponge genus Leucetta and from the class Calcarea. This work contributes expands the knowledge of the chemical diversity of calcareous marine sponges, and the chemotaxonomic significance of the isolates is also discussed.

Source: Biochemical Systematics and Ecology - December 5, 2019 Category: Biochemistry Source Type: research