ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis?

ETAA1 activates the master checkpoint kinase ATR. Bass and Cortez (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810058) recently reported an intra-mitotic function of ETAA1 that safeguards chromosome stability. In this issue, Achuthankutty et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905064) describe a mechanism controlling the ATR-activating potential of ETAA1 in S phase to preserve chromosome stability.

Source: Journal of Cell Biology - December 1, 2019 Category: Cytology Authors: Gonzalez Besteiro, M. A., Gottifredi, V. Tags: Spotlight Source Type: research