Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease [RESEARCH ARTICLE]

In conclusion, mouse whole-brain 3D imaging is ideal for unbiased automated counting and densitometric analysis of TH-positive cells. The LSFM–deep learning pipeline tracked brain-wide changes in catecholaminergic pathways in the MPTP mouse model of PD, and may be applied for preclinical characterization of compounds targeting dopaminergic neurotransmission.

Source: DMM Disease Models and Mechanisms - November 21, 2019 Category: Biomedical Science Authors: Roostalu, U., Salinas, C. B. G., Thorbek, D. D., Skytte, J. L., Fabricius, K., Barkholt, P., John, L. M., Jurtz, V. I., Knudsen, L. B., Jelsing, J., Vrang, N., Hansen, H. H., Hecksher-Sorensen, J. Tags: Neurodegenerative disorders RESEARCH ARTICLE Source Type: research