TNFa alter cholesterol metabolism in human macrophages via PKC-theta-dependent pathway

Conclusions:
Our results suggest TNFa alter cholesterol metabolism in human macrophages through the inhibition of Reverse cholesterol transport and enhancing cholesterol uptake via PKC-theta-dependent pathway, implicating a potential mechanism of inflammation on atherogenic effects.

Source: BMC Biochemistry - August 3, 2013 Category: Biochemistry Authors: A Sha MaQian ZhangZhi Song Source Type: research