Quantitative morphology of the lung and its importance in investigations of pulmonary diseases in mice

Publication date: Available online 28 November 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Wilfried KleinThe morphology of the mouse respiratory system has been studied in several different models of respiratory diseases, but quantitative morphological methods such as stereology are still only employed sporadically. This review discusses the use of stereology as a tool to understand the morphology of the mouse respiratory system and its link to the study of pulmonary mechanics. An integrated approach to study lung function in mice is being proposed, by combining non-invasive and invasive methods to analyze pulmonary mechanics, coupled with stereological investigations of lung morphology.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research