Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise

Publication date: Available online 27 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): M.L. Woodward, A.H. Ker, A.M. Barr, C.L. Beasley, C. Hercher, H.N. Boyda, R.M. Procyshyn, W.G. Honer, D.J. LangAbstractAerobic exercise has been associated with hippocampal plasticity, both in healthy adults and in psychosis patients, but its impact on cortical regions remains unclear. The entorhinal cortex serves as a critical gateway for the hippocampus, and recent studies suggest that this region may also be impacted following an exercise regime. In order to investigate the effects of antipsychotic medications and exercise on the entorhinal cortex, female rats were chronically administered either olanzapine or vehicle and were either sedentary or had access to a running wheel for 9 weeks. Olanzapine-treated rats had decreased medial entorhinal cortical thickness compared to vehicle-treated rats. A statistically significant interaction was observed for layer II of the entorhinal cortex, with exercising rats having significantly greater thickness compared to sedentary rats in the vehicle group, but not the olanzapine group. Greater total entorhinal and lateral entorhinal cortical thickness was associated with greater average activity. In exercising rats, decreasing glucose intolerance was associated with larger total entorhinal and layer II cortical thickness. Lower fasting insulin levels were associated with greater total entorhinal, lateral entorhinal, and layer II...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research