Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study

In this study, the taste-masking efficiency of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) was assessed by Euclidean distances on a principle component analysis (PCA) map with the SA402B Taste Sensing System, and the host-guest interactions were investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), nuclear magnetic resonance (NMR) spectroscopy and scanning electron microscopy (SEM). Biosensor evaluation and characterization of the inclusion complex indicated that atomoxetine HCl could actively react with 2-hydroxypropyl-β-cyclodextrin.Graphical abstractThe quantitative bitterness of atomoxetine hydrochloride was measured by a biosensor system using quinine hydrochloride as a reference. HP-β-CyD/atomoxetine hydrochloride inclusion complex was prepared to mask the bitter taste, and the efficiency of bitterness suppression by HP-β-CyD was evaluated by biosensor system. Following DSC, X-ray, H- NMR and SEM analysis, it was found that atomoxetine hydrochloride actively reacted with HP-β-CyD.
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research