Endurance training improves plasma superoxide dismutase activity in healthy elderly

Publication date: Available online 22 November 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Roberta Ceci, Guglielmo Duranti, Ester Sara Di Filippo, Danilo Bondi, Vittore Verratti, Christian Doria, Daniela Caporossi, Stefania Sabatini, Ivan Dimauro, Tiziana PietrangeloAbstractWe aimed to characterize the plasma redox homeostasis as underlying physiological mechanisms of specific training on healthy elderly. 51 healthy volunteers were trained to endurance, resistance, Neuro-Muscular Electrical Stimulation for 12 weeks, 3 sessions/w, all applied to lower limbs. We assessed ex-post quadriceps’ maximal voluntary contraction, handgrip strength, five-times-sit to stand and timed up-and-go tests, oxidative damage (lipid peroxidation, protein carbonyl groups), antioxidant enzyme activities (superoxide dismutase, Catalase, Glutathione peroxidase, Glutathione homeostasis), free thiols and total antioxidant status. We found significant difference in ex-post × protocol and in post-hoc analysis specifically for plasma superoxide dismutase activity in endurance training.Graphical abstractMVC: isometric Maximal Voluntary Contraction; HS: Handgrip Strength; FTTST: Five Times Sit-to-Stand Test; TUG: Timed Up-and-Go test; FT: Free Thiols; SOD: total Superoxide Dismutase; MDA: Malondialdehyde: CAT: Catalase; GSH: reduced Glutathione; GSSG: oxidized Glutathione; GPx: Glutathione Peroxidase; TAS: Total Antioxidant Status; PC: Protein Carbonyl groups
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research