Blood derived products – background and technology and clinical application in osteoarthritis

Publication date: Available online 21 November 2019Source: Sports Orthopaedics and TraumatologyAuthor(s): Vivek Jeyakumar, Olga Kuten, Stefan NehrerSummaryThe physiological support of blood-derived products for tissue repair and regeneration is gaining attention for many robust applications in the field of regenerative medicine. Platelet-rich plasma (PRP) is one of the prominent blood-derived product widely used for in vitro cell culture supplementation and therapeutical interventions. The amount of growth factors and cytokines present in the platelet alpha granules from PRP provides all necessary anabolic factors to maintain cell propagation, cell differentiation, and phenotype stabilization for in vitro cell culture. Divergences existing from different preparation protocols of PRP is consequential to existing various sub-categorical plasma enriched products across laboratories worldwide. This review outlines the background, methodologies, and current knowledge about human blood-derived products and underlines its advantage and disadvantage in a wide range of applications.ZusammenfassungDie physiologische Unterstützung Blut abstammender Produkte für die Gewebereparatur und -regeneration gewinnt bei vielen Anwendungen im Bereich der regenerativen Medizin an Aufmerksamkeit. Thrombozytenreiches Plasma (PRP) ist eines der bekanntesten Blutprodukte, das häufig als Supplement in der In-vitro-Zellkultur und für therapeutische Anwendungen verwendet wird. Die Menge an Wachstumsfa...
Source: Sports Orthopaedics and Traumatology - Category: Sports Medicine Source Type: research