Progress in DNA Tetrahedral Nanomaterials and Their Functionalization Research

Publication date: November 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 11Author(s): Li-Xing YU, Rui ZHAI, Xiao-Yun GONG, Jie XIE, Ze-Jian HUANG, Mei-Ying LIU, You JIANG, Xin-Hua DAI, Xiang FANG, Xiao-Ping YUAbstractDNA tetrahedral nanomaterials have been widely used in the fields of biosensing, drug delivery, bioimaging and separation analysis because of their high stability, good biocompatibility and easy modification. Through different designs, specific functional molecules can be modified at DNA tetrahedral vertices, DNA tetrahedral cage structures, DNA double helix structures or DNA tetrahedron arms. The advantages of the materials combine well with the specific functions of the active molecules. This paper reviewed the development of DNA nanotechnology, and introduced four different functional modifications of DNA tetrahedron nanomaterials and their research status.Graphical abstractFunctionalized DNA tetrahedral nanomaterials combine the advantages of DNA tetrahedrons with the specific functions of modified molecules, and have been widely studied and applied in the fields of drug delivery, biosensors, bioimaging and separation analysis. In this review, we discuss the four different types functional modifications of DNA tetrahedron and their research application status.
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research