A Phase II randomized controlled trial for lung and diaphragm protective ventilation (Real-time Effort Driven VENTilator management)

Lung Protective mechanical ventilation (MV) of critically ill adults and children is lifesaving but it may decrease diaphragm contraction and promote Ventilator Induced Diaphragm Dysfunction (VIDD). An ideal MV strategy would balance lung and diaphragm protection. Building off a Phase I pilot study, we are conducting a Phase II controlled clinical trial that seeks to understand the evolution of VIDD in critically ill children and test whether a novel computer-based approach (Real-time Effort Driven ventilator management (REDvent)) can balance lung and diaphragm protective ventilation to reduce time on MV.

Source: Contemporary Clinical Trials - November 14, 2019 Category: Radiology Authors: Robinder G. Khemani, Justin Hotz RCP, Margaret Klein, Jeni Kwok, Caron Park, Christiane Lane, Erin Smith RCP, Kristen Kohler RCP, Anil Suresh RCP, Dinnel Medina RCP, Patrick A. Ross, Timothy Deakers, Fernando Beltramo, Lara Nelson, Shilpa Shah, Anoopindar Source Type: research