The N-AcetylCysteine and RAMipril in Takotsubo Syndrome Trial (NACRAM): Rationale and design of a randomised controlled trial of sequential N-Acetylcysteine and ramipril for the management of Takotsubo Syndrome

Takotsubo Syndrome(TTS), contrary to historical reports, is now increasingly recognised to be associated with substantial mortality and morbidity, both in the short- and long-term. Although TTS is often precipitated by a catecholamine “pulse”, in-hospital hypotension is a common occurrence, increasing the risk of mortality. Furthermore, despite the transient catecholamine stimulus, there is increasing evidence that there are significant long term sequelae, including persistently impaired left ventricular(LV) systolic dysfunct ion, myocardial oedema with fibrosis, as well as persistent impairment of quality of life.

Source: Contemporary Clinical Trials - November 14, 2019 Category: Radiology Authors: Gao Jing Ong, Thanh Ha Nguyen, Jeanette Stansborough, Sven Surikow, Gnanadevan Mahadavan, Matthew Worthley, John Horowitz Source Type: research