Verapamil and collagenase differentially affect collagen metabolism in experimental model of Peyronie's disease

ConclusionVER and COLL attenuate collagen biosynthesis in both fibroblast models. The VER-dependent inhibition of collagen biosynthesis was accompanied by inhibition of DNA biosynthesis at high prolidase activity, while COLL affected this process through inhibition of prolidase activity at high rate of DNA biosynthesis. It shows that anti-fibrotic activity of VER/COLL and anti-inflammatory activity of VER may represent approach to establish standard treatment of PD.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research