Perforin gene PRF1 c.900C> T polymorphism and HIV-1 vertical transmission

This study aims at evaluating the role of the c.900C> T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. The PRF1 c.900C> T polymorphism was genotyped in 331 children from Zambia using a Taqman probe on a Real Time PCR platform. The PRF1 c.900C> T C/T genotype was more frequent among HIV-1 exposed but non-infected children than in HIV-1 positive cases, and the results were confirmed among children infected during breastfeeding. PRF1 c.900C> T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research