Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis With Poor Kidney Function: A Subgroup Analysis of the Aspreva Lupus Management Study

This post hoc subgroup analysis of the ALMS trial (comparing MMF to cyclophosphamide in lupus nephritis) specifically assessed patients with GFR < 30 ml/min/1.73m2. No difference was detected in the primary outcome of response to treatment (decrease in proteinuria and stabilization or improvement of serum creatinine level). The accompanying editorial asks whether post-hoc subgroup analyses should change treatment patterns: https://readbyqxmd.com/read/23582251/mycophenolate-mofetil-in-severe-lupus-nephritis-should-post-hoc-analyses-change-treatment-patterns : Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis Should mycophenolate mofetil replace cyclophosphamide as first-line therapy for severe lupus nephritis? Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Lupus Source Type: research