Steroidal constituents from Helleborus thibetanus and their cytotoxicities

In this study, compounds 2–13 were evaluated for their cytotoxic activities against HCT116, A549 and HepG2 tumor cell lines in vitro. Among them, compound 8 (thibetanoside C) showed cytotoxicities against A549 cells(IC50 39.6 ± 1.9 μmol·L−1) and HepG2 cells(IC50 41.5 ± 1.1 μmol·L−1), respectively. Compound 9 (23S, 24S)-24-[(O-β-D-fucopyranosyl)oxy]-3β, 23-dihydroxy-spirosta-5, 25(27)-diene-1β-ylO-(4-O-acetyl- α-L-rhamnopyranosyl)-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside) showed cytotoxicity against HCT116 cells(IC50 33.6 ± 2.1 μmol·L−1).
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research