PKCgamma receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats
Conclusions:
The modified SPS alters visceral sensitivity to CRD, and contributes to the maintenance of visceral hyperalgesia, which is associated with enhanced PKCgamma expression in the spinal cord. Functional blockade of the PKCgamma receptors attenuates SPS-induced visceral hyperalgesia. Thus, the present study identifies a specific molecular mechanism for visceral hyperalgesia which may pave the way for novel therapeutic strategies for PTSD-like conditions.
Source: Molecular Pain - Category: Molecular Biology Authors: Yu-Qin HeQiang ChenLei JiZheng-Guo WangZhi-Hong BaiRobert StephensMin Yang Source Type: research
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