Diabetes Type 2 and Kisspeptin: Central and Peripheral Sex-Specific Actions

Publication date: November 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 11Author(s): Monika Dudek, Kamil Ziarniak, Marie-Line Cateau, Laurence Dufourny, Joanna Helena SliwowskaKisspeptin (KP) plays a major role in the regulation of reproduction governed by the hypothalamic–pituitary–gonadal (HPG) axis. However, recent findings suggest that the KP system is present not only centrally (at the level of the hypothalamus), but also in the peripheral organs crucial for the control of metabolism. The KP system is sexually differentiated in the hypothalamus, and it is of particular interest to study whether sex-specific responses to type 2 diabetes (DM2) exist centrally and peripherally. As collection of data is limited in humans, animal models of DM2 are useful to understand crosstalk between metabolism and reproduction. Sex-specific variations in the KP system reported in animals suggest a need for the development of gender specific therapeutic strategies to treat DM2.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research