From a syncytium to mononucleate cells and back: Yki and JNK in symphony

Alary muscle syncytia in Drosophila larvae undergo a remarkable process of dedifferentiation into single cells that then fuse to become ventral longitudinal muscle in the adult. In this issue, Schaub et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201905048) identify the Hippo and JNK signaling pathways as key regulators of this process of developmental remodeling of cell fate.

Source: Journal of Cell Biology - November 3, 2019 Category: Cytology Authors: Chaturvedi, D., VijayRaghavan, K. Tags: Cell Cycle and Division, Development Spotlight Source Type: research