Death by microglia

The roles of microglia and ApoE in tauopathies, such as Alzheimer’s disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Neuroinflammation, Innate Immunity and Inflammation, Neuroscience Insights Source Type: research