Cytogenetic and Molecular Genetic Characterization of KMT2A-PTD Positive Acute Myeloid Leukemia in Comparison to KMT2A-Rearranged Acute Myeloid Leukemia

Publication date: Available online 1 November 2019Source: Cancer GeneticsAuthor(s): Calogero Vetro, Torsten Haferlach, Manja Meggendorfer, Anna Stengel, Sabine Jeromin, Wolfgang Kern, Claudia HaferlachAbstractTo define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvements and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD by performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients> 60 years. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p<0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS.
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research