Mitochondrial complex IV is lost in neurons in the cuprizone mouse model

ConclusionNeurons are affected by cuprizone-treatment. Whether this mitochondrial dysfunction acts as a subclinical trigger for demyelination and the long-term axonal degeneration that proceeds after cuprizone treatment stops remains unclear.Graphical abstractThe cartoon gives an overview of the assembly of cytochrome oxidase and sites at which the copper is inserted. Mitochondrial DNA encoded subunits form the core of the complex and copper, an essential component of electron transport mechanism, is incorporated into the redox centres of both COX 1 and COX2. Multiple assembly factors are required for the addition of heme and copper and the correct assembly with the nuclear encoded components of the complex.
Source: Mitochondrion - Category: Biochemistry Source Type: research