Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes [RESEARCH ARTICLE]

In conclusion, our conditional SMARCAL1 knockdown model in iPSCs may represent a powerful model when studying pathogenetic mechanisms of severe Schimke immuno-osseous dysplasia.

Source: DMM Disease Models and Mechanisms - October 16, 2019 Category: Biomedical Science Authors: Pugliese, G. M., Salaris, F., Palermo, V., Marabitti, V., Morina, N., Rosa, A., Franchitto, A., Pichierri, P. Tags: Stem Cells, Rare diseases RESEARCH ARTICLE Source Type: research