Identification of novel Kirrel3 gene splice variants in adult human skeletal muscle

Conclusion:
The results presented here demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. Importantly, mRNA of all splice variants was not always present, a finding with potential physiological relevance. These initial discoveries highlight the need for more molecular and functional studies to understand the role of Kirrel3 in human skeletal muscle.

Source: BMC Physiology - December 9, 2014 Category: Physiology Authors: Peter DurcanJohannes ConradieMari Van deVyverKathryn Myburgh Source Type: research