miRNAs as Therapeutic Targets in Inflammatory Disease

Publication date: Available online 29 October 2019Source: Trends in Pharmacological SciencesAuthor(s): Qianjin Lu, Ruifang Wu, Ming Zhao, Antonio Garcia-Gomez, Esteban BallestarIn the past decade, we have witnessed considerable developments in understanding the roles and functions of miRNAs. In parallel, the identification of alterations in miRNA expression in inflammatory disease indicates their potential as therapeutic targets. Pharmacological treatments targeting abnormally expressed miRNAs for inflammatory diseases are not yet in clinical practice; however, some small compounds and nucleic acids targeting miRNAs have shown promise in preclinical development. Here, we focus on recent advances in understanding miRNA deregulation in inflammatory diseases and provide an overview of the current development of miRNA-based therapeutics in these diseases with an emphasis on newly discovered miRNA therapeutic targets.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research